Bioorthogonal oxime ligation mediated in vivo cancer targeting
نویسندگان
چکیده
Department of Materials Science and Urbana–Champaign, 1304 West Green S [email protected]; Fax: +1-217-333-2736 Department of Pharmaceutical Science, Guangzhou, Guangdong, 510006, China Department of Bioengineering, University o IL 61801, USA † Electronic supplementary informatio characterization of compounds and nan cell labelling with liposomes, PET/CT im 10.1039/c5sc00063g ‡ Contributed equally. Cite this: Chem. Sci., 2015, 6, 2182
منابع مشابه
Bioorthogonal oxime ligation mediated in vivo cancer targeting† †Electronic supplementary information (ESI) available: Synthesis and characterization of compounds and nanoparticles, in vitro and in vivo tumor cell labelling with liposomes, PET/CT imaging and biodistribution. See DOI: 10.1039/c5sc00063g Click here for additional data file.
Current cancer targeting relying on specific biological interaction between cell surface antigen and respective antibody or its analogue has proven to be effective in the treatment of different cancers; however, this strategy has its own limitations, such as heterogeneity of cancer cells and immunogenicity of the biomacromolecule binding ligands. Bioorthogonal chemical conjugation has emerged a...
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